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KMID : 1144820190250010007
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대한의생명과학회지
2019 Volume.25 No. 1 p.7 ~ p.14
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A Comparative Study of [F-18] Florbetaben (FBB) PET Imaging, Pathology, and Cognition between Normal and Alzheimer Transgenic Mice
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Thapa Ngeemasara
Jeong Young-Jin
Kang Hyeon
Choi Go-Eun
Yoon Hyun-Jin
Kang Do-Young
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Abstract
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Alzheimer's disease (AD) is highly prevalent in dementia, with no specifically effective treatment having yet been discovered. Amyloid plaques are one of the key hallmarks of AD. Transgenic mouse models exhibiting Alzheimer's disease-like pathology have been widely used to study the pathophysiology of Alzheimer's disease. In this study, we showed an age-dependent correlation between cognitive function, pathological findings, and [F-18] Florbetaben (FBB) PET images. Nineteen transgenic mice (12 with AD, 7 with controls) were used for this study. We observed an increase in β-Amyloid deposition (Aβ) in brain tissue and [F-18] FBB amyloid PET imaging in the AD group. The [F-18] FBB data showed a mildly negative trend with cognitive function. Pathological findings were negatively correlated with cognitive functions. These finding suggests that amyloid beta deposition can be well-monitored with [F-18] FBB PET and a decline in cognitive function is related to the increase in amyloid plaque burden.
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KEYWORD
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[F-18] FBB, Tg2576 mouse, Alzheimer's disease, β-Amyloid, PET imaging
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